Anxiolytic Natural Plant Extract

- Jul 12, 2018-

As one of the most common problems in human psychological disorders, anxiety has always been a relatively active field of psychology, but there are many different perspectives on the causes of anxiety. Anxiety disorder is an anxiety-based neurosis consisting mainly of generalized anxiety (GAD) and acute anxiety attack (GAP). At present, the main methods for treating anxiety disorders are psychotherapy and drug therapy. Psychotherapy is influenced by subjective factors and has a long period of time, while drug therapy mainly uses benzodiazepines, non-benzodiazepines, and antidepressants. And ?- adrenal receptor inhibitors, etc., although these Western medicines have a quick effect, but they will lead to certain compliance and adverse reactions, and finding a drug with effective and adverse reactions has become a hot spot of concern. Natural medicines have become the subject of scholars' research because of their natural and more and more researches indicating that their effects are obvious and their adverse reactions are small. At present, the anxiolytic effects of natural plants are mainly focused on verifying their anxiolytic effects with various animal models and analyzing their components in order to find effective ingredients to develop new drugs. However, there is little discussion about its mechanism of action, which may be related to the complexity of the pathological mechanism of anxiety and the diversity of natural plant components and its role through multiple targets. There are many traditional natural plants in China that have anti-anxiety effects, such as ginkgo biloba, ginseng, jujube kernel, forest frog, etc. [Now some natural plant varieties abroad are summarized and reviewed, hoping to help future researchers.

Passiflora Linn is the largest genus of Passifloraceae, and contains about 500 species, all of which are herbaceous or woody perennials. Mainly distributed in tropical and subtropical regions. Pink Passiflora was first discovered in Peru by the Spanish explorer Monardus. It is one of the most thoroughly studied species of Passiflora and its anti-anxiety effect is relatively certain. It is followed by purple fruit passionflower and wing Passionflower and so on. However, the anti-anxiety active ingredients of Passionflower and its mechanism of action are not very clear. In recent years, studies have shown that the anxiolytic active ingredients of Passiflora may involve gamma aminobutyric acid (GABA), lipophilic substances and chrysin, which are mainly directly or indirectly acting on GABA benzodiazepine receptor complexes. The body has exerted anti-anxiety effects, and studies have shown that benzoflavonoids are the active constituents of the anti-anxiety effect of pink passionflower. Studies have shown that it regulates the transforming energy of neurosteroids, β-carboline quinone by the inhibition of aromatase. Alkaloids are considered to be another major component of the anxiolytic effect of Passionflower, which inhibits the metabolism of monoamine neurotransmitters (5-HT, norepinephrine, dopamine, etc.) by inhibiting mitochondrial monoamine oxidase activity. Decreased, up-regulated the level of monoamine in the synaptic cleft, thus achieving anti-anxiety.