Plant Extract Separation Technology

- Jul 19, 2018-

Separation technique

1) Resin separation technology Resin technology has been successfully applied in industrial decolorization, environmental protection, drug analysis, antibiotic extraction and separation. The separation and concentration of the phytochemical components have also been extremely successful. For example, for ginkgo biloba, the current resin separation technology can achieve a collection rate of 90% of ginkgo flavonoids; it can concentrate gingko flavonoids at one time to make it more than 50%; it can also remove most (more than 99.5%) as The harmful component of ginkgolic acid is made lower than 5 ppm, and the loss of active ingredient is controlled to be less than 3%.

2) Industrial extraction technology includes: 1 organic solvent extraction technology; 2 carbon dioxide supercritical fluid extraction technology, which was introduced in the 1990s, using high-pressure (350-500 bar) liquid CO2 to extract plant active ingredients, resulting in high purity The yield is high and the extractant is non-polluting. However, due to the high work pressure, the equipment requirements are high, and currently only the pilot level; 3 new chlorofluorocarbon solvent extraction, such as the British recently invented "Klea" (HFC134α, 1,1,1,2 tetrafluorohexane) An inert solvent that can be extracted at low pressure room temperature to save energy and avoid thermal damage.

3) Analytical detection technology: Chinese herbal extracts require quantitative analysis of the target components and harmful substances, or comparison with standard products, or fingerprints, and strict testing of raw materials, production processes and finished products. For example, Natural Sunshine Co., Ltd. conducted 150 tests from raw materials to finished products. Therefore, in the quality control of traditional Chinese medicine extracts, modern analytical instruments are indispensable, and they are most widely used in HPLC. At the same time, methods and instruments such as GC, HPCE, GC-MS, HPLC-MS, UV and atomic spectroscopy are often used. Used. According to statistics, about 75% of the extracts of traditional Chinese medicines were tested by HPLC, while only 10.9% of the proprietary Chinese medicines contained in the pharmacopoeia were used. Companies with lower levels of technology often do not have the ability to analyze instruments, and commercial enterprises rarely have these conditions.

Technical standards At present, most of the plant extracts do not have national standards or industry standards. Most of the enterprises use the quality clauses in the contract as the basis for product delivery. The detection methods of product quality are confusing, which brings obstacles to production and operation. The development of the industry presents challenges. A small number of enterprises in the industry have initially established an enterprise technical standard system, medicinal materials quality standards and extract quality standards, medicinal materials planting procedures, extract production process regulations and inspection operating procedures.